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A Phase II Clinical Trial of Anti-PD-1 mAb Therapy Alone or With Metabolic Modulators to Reverse Tumor Hypoxia and Immune Dysfunction in Solid Tumor Malignancies

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Trial Profile

A Phase II Clinical Trial of Anti-PD-1 mAb Therapy Alone or With Metabolic Modulators to Reverse Tumor Hypoxia and Immune Dysfunction in Solid Tumor Malignancies

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 01 Jul 2026

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At a glance

  • Drugs Metformin (Primary) ; Nivolumab (Primary) ; Pembrolizumab (Primary) ; Rosiglitazone (Primary)
  • Indications Adenocarcinoma; Gastric cancer; Head and neck cancer; Liver cancer; Malignant melanoma; Non-small cell lung cancer; Oesophageal cancer; Renal cell carcinoma; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Focus Therapeutic Use

Most Recent Events

  • 23 Jun 2026 Planned End Date changed from 2 Oct 2027 to 30 Apr 2032.
  • 24 Apr 2026 Planned End Date changed from 30 Apr 2032 to 2 Oct 2027.
  • 14 Jul 2023 Planned End Date changed from 1 Dec 2029 to 30 Apr 2032.

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