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A Randomized, Single-Masked, Active-Controlled Phase 2 Study of the Safety, Tolerability, and Efficacy of Repeated Doses of High-Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration

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Trial Profile

A Randomized, Single-Masked, Active-Controlled Phase 2 Study of the Safety, Tolerability, and Efficacy of Repeated Doses of High-Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 05 May 2025

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At a glance

  • Drugs Aflibercept (Primary)
  • Indications Choroidal neovascularisation; Wet age-related macular degeneration
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Acronyms CANDELA
  • Sponsors Regeneron Pharmaceuticals

Most Recent Events

  • 28 Apr 2025 According to Regeneron Pharmaceuticals media release, data from this trial will be presented at the Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting
  • 29 Apr 2024 According to a Bayer media release, the Pooled safety analysis of the CANDELA, PHOTON, and PULSAR trials will be presented at the the Annual Meeting of The Association for Research in Vision and Ophthalmology (arvo.org), in Seattle, Washington, 5-9 May 2024.
  • 01 Sep 2023 Primary endpoint (Proportion of patients without retinal fluid in the center subfield) has not been met, according to Results published in the JAMA Ophthalmolog.

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