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INNATE: Immunotherapy During Neoadjuvant Therapy for Rectal Cancer, a Phase II Randomized Multi-center Trial With and Without APX005M, an Anti-CD40 Agonist

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Trial Profile

INNATE: Immunotherapy During Neoadjuvant Therapy for Rectal Cancer, a Phase II Randomized Multi-center Trial With and Without APX005M, an Anti-CD40 Agonist

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 15 Oct 2025

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At a glance

  • Drugs Sotigalimab (Primary) ; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Adenocarcinoma; Rectal cancer
  • Focus Therapeutic Use
  • Acronyms INNATE

Most Recent Events

  • 07 Oct 2025 Planned End Date changed from 1 Sep 2025 to 5 Dec 2025.
  • 07 Oct 2025 Planned primary completion date changed from 1 Sep 2025 to 5 Dec 2025.
  • 19 Dec 2023 Planned End Date changed from 1 Nov 2023 to 1 Sep 2025.

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