Trial Profile

INNATE: Immunotherapy During Neoadjuvant Therapy for Rectal Cancer, a Phase II Randomized Multi-center Trial With and Without APX005M, an Anti-CD40 Agonist

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 04 Feb 2026

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At a glance

Drugs Sotigalimab (Primary) ; Fluorouracil; Folinic acid; Oxaliplatin
Indications Adenocarcinoma; Rectal cancer
Focus Therapeutic Use
Acronyms INNATE

Most Recent Events

28 Jan 2026 Planned End Date changed from 5 Dec 2025 to 31 Jan 2026.
28 Jan 2026 Planned primary completion date changed from 5 Dec 2025 to 31 Jan 2026.
07 Oct 2025 Planned End Date changed from 1 Sep 2025 to 5 Dec 2025.

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