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A Randomized, Open Label, Multicenter Phase II Study Evaluating the Efficacy and Safety of Capmatinib (INC280) Plus Pembrolizumab Versus Pembrolizumab Alone as First Line Treatment for Locally Advanced or Metastatic Non-small Cell Lung Cancer With PD-L1≥ 50%

Trial Profile

A Randomized, Open Label, Multicenter Phase II Study Evaluating the Efficacy and Safety of Capmatinib (INC280) Plus Pembrolizumab Versus Pembrolizumab Alone as First Line Treatment for Locally Advanced or Metastatic Non-small Cell Lung Cancer With PD-L1≥ 50%

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 12 Feb 2024

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At a glance

  • Drugs Capmatinib (Primary) ; Pembrolizumab (Primary)
  • Indications Non-small cell lung cancer; Squamous cell cancer
  • Focus Therapeutic Use
  • Sponsors Novartis; Novartis Pharma A.G.; Novartis Pharmaceuticals
  • Most Recent Events

    • 15 Mar 2023 According to European Clinical Trials Database record, this trial has been completed in Spain.
    • 13 Feb 2023 Status changed from active, no longer recruiting to discontinued as per sponsor decision to terminate the due to the lack of tolerability observed in patients treated with capmatinib and pembrolizumab in the combination arm as compared to patients treated with pembrolizumab alone in the pembrolizumab single agent arm.
    • 06 Feb 2023 Planned End Date changed from 17 Jan 2023 to 7 Feb 2023.

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