Trial Profile

NASH EXploratory Single and COmbination Treatment (NEXSCOT): An Open Label, Multicenter, Platform Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of Various Single and Combination Treatments in Patients With Non-alcoholic Fatty Liver Disease (NAFLD) Who Manifest a Non-alcoholic Steatohepatitis (NASH)-Like Biomarker Phenotype

Status: Discontinued

Phase of Trial: Phase II

Latest Information Update: 30 Nov 2025

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At a glance

Drugs LYS-006 (Primary) ; Tropifexor (Primary)
Indications Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis
Focus Adverse reactions
Acronyms NEXSCOT
Sponsors Novartis Pharmaceuticals

14 Mar 2022 Status changed from recruiting to discontinued.
07 Feb 2022 Planned primary completion date changed from 29 Jul 2022 to 31 Jul 2022.
26 Jan 2022 This trial has been discontinued in Germany according to European Clinical Trials Database record.

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