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Determination of analgesic equipotent doses of inhaled metoxyflurane vs. intravenous fentanyl using cold pressor test (CPT) in volunteers: A randomized, double blind, placebo-controlled crossover study

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Trial Profile

Determination of analgesic equipotent doses of inhaled metoxyflurane vs. intravenous fentanyl using cold pressor test (CPT) in volunteers: A randomized, double blind, placebo-controlled crossover study

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 12 Oct 2021

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At a glance

  • Drugs Methoxyflurane (Primary) ; Fentanyl
  • Indications Acute pain
  • Focus Therapeutic Use

    • Most Recent Events

    • 03 Mar 2021 Primary endpoint (NRS (numeric rating scale) scores during the second CPT, which starts 5 minutes after drug administration and lasts for 90 seconds. (inhaled metoxyflurane vs. intravenous fentanyl 50 mg) has not been met, according to the results published in the British Journal of Anaesthesia.
    • 03 Mar 2021 Primary endpoint (NRS (numeric rating scale) scores during the second CPT, which starts 5 minutes after drug administration and lasts for 90 seconds. (inhaled metoxyflurane vs. intravenous fentanyl 25 mg) has been met, according to the results published in the British Journal of Anaesthesia.
    • 03 Mar 2021 Results accessing the equi-analgesic doses of inhaled methoxyflurane compared with fentanyl in volunteers for acute pain, published in the British Journal of Anaesthesia.

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