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Phase I/II Study of the Safety, Pharmacokinetics, and Preliminary Clinical Activity of BT5528 in Patients With Advanced Malignancies Associated With EphA2 Expression

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Trial Profile

Phase I/II Study of the Safety, Pharmacokinetics, and Preliminary Clinical Activity of BT5528 in Patients With Advanced Malignancies Associated With EphA2 Expression

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 26 Aug 2026

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At a glance

  • Drugs Nivolumab (Primary) ; Nuzefatide pevedotin (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Bladder cancer; Gastric cancer; Gastrointestinal cancer; Head and neck cancer; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Solid tumours; Triple negative breast cancer; Urogenital cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Bicycle Therapeutics

Most Recent Events

  • 18 Mar 2026 According to a Bicycle Therapeutics media release, data from the trial will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2026, taking place April 17-22 in San Diego.
  • 30 Oct 2025 According to a Bicycle Therapeutics media release, the data from the trial will be presented at a scientific conference in the first half of 2026.
  • 25 Feb 2025 According to a Bicycle Therapeutics media release, initial EphA2 human imaging data expected in 2H 2025.

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