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AMLM25: An ALLG Phase 2 study to Investigate Novel Triplets to Extend Remission with VENetoclax in Elderly (INTERVENE) Acute Myeloid Leukaemia

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Trial Profile

AMLM25: An ALLG Phase 2 study to Investigate Novel Triplets to Extend Remission with VENetoclax in Elderly (INTERVENE) Acute Myeloid Leukaemia

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 12 Feb 2025

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At a glance

  • Drugs Cytarabine (Primary) ; Midostaurin (Primary) ; Venetoclax (Primary) ; Pracinostat
  • Indications Acute myeloid leukaemia
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 13 Dec 2022 Results of Sub-Analysis assessing whether triplet schedule would suppress emergence of kinase-activating mutations on VEN-based therapy, presented at the 64th American Society of Hematology Annual Meeting and Exposition
    • 14 Dec 2021 Status changed from not yet recruiting to recruiting as per results presented at the 63rd American Society of Hematology Annual Meeting and Exposition
    • 14 Dec 2021 Results (N=32) of the dose-finding safety run-in phase of the study presented at the 63rd American Society of Hematology Annual Meeting and Exposition

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