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A Randomized, Double-Blind, Phase III Study of Carboplatin-Paclitaxel/Nab-Paclitaxel Chemotherapy With or Without Pembrolizumab (MK-3475) in First Line Metastatic Squamous Non-small Cell Lung Cancer Subjects (KEYNOTE-407)

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Trial Profile

A Randomized, Double-Blind, Phase III Study of Carboplatin-Paclitaxel/Nab-Paclitaxel Chemotherapy With or Without Pembrolizumab (MK-3475) in First Line Metastatic Squamous Non-small Cell Lung Cancer Subjects (KEYNOTE-407)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 04 Oct 2024

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At a glance

  • Drugs Pembrolizumab (Primary) ; Carboplatin; Paclitaxel
  • Indications Non-small cell lung cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms KEYNOTE-407 China Extension
  • Sponsors Merck Sharp & Dohme Corp.

Most Recent Events

  • 28 Sep 2023 Status changed from active, no longer recruiting to completed.
  • 12 Sep 2023 Results of pooled analysis of 5-year outcomes , from KEYNOTE-407 China Extension, KEYNOTE-407, KEYNOTE-189 and KEYNOTE-189 Japan extension presented at the 24th World Conference on Lung Cancer
  • 13 Dec 2022 Planned End Date changed from 21 Mar 2023 to 11 Sep 2023.

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