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A First-in-human, Two-part Clinical Study to Assess the Safety, Tolerability and Activity of IV Doses of ICT01 as Monotherapy and in Combination With a Checkpoint Inhibitor, in Patients With Advanced-stage, Relapsed/Refractory Cancer

Trial Profile

A First-in-human, Two-part Clinical Study to Assess the Safety, Tolerability and Activity of IV Doses of ICT01 as Monotherapy and in Combination With a Checkpoint Inhibitor, in Patients With Advanced-stage, Relapsed/Refractory Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 06 Jun 2025

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At a glance

  • Drugs Azacitidine (Primary) ; ICT 01 (Primary) ; Pembrolizumab (Primary) ; Venetoclax (Primary)
  • Indications Acute myeloid leukaemia; Adenocarcinoma; Advanced breast cancer; Bladder cancer; Carcinoma; Cervical cancer; Colon cancer; Colorectal cancer; Diffuse large B cell lymphoma; Follicular lymphoma; Gastric cancer; Haematological malignancies; Head and neck cancer; Lymphoma; Malignant melanoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Precursor cell lymphoblastic leukaemia-lymphoma; Prostate cancer; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms EVICTION
  • Sponsors ImCheck Therapeutics

Most Recent Events

  • 22 May 2025 Results presented in a ImCheck Therapeutics media release.
  • 30 Apr 2025 Results (n=40) reporting preliminary efficacy, safety, pharmacodynamics and dose selection of ICT01 data in the phase 1 portion of this trial presented at the 116th Annual Meeting of the American Association for Cancer Research
  • 23 Apr 2025 According to a ImCheck media release, company will present data from this study in an oral presentation at the upcoming American Society of Clinical Oncology (ASCO) Annual Meeting 2025, taking place from May 30 to June 3, in Chicago, Illinois, USA.

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