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A Safety, Pharmacokinetic and Efficacy Study of a y-Secretase Inhibitor, Nirogacestat (PF-03084014), in Children and Adolescents With Progressive, Surgically Unresectable Desmoid Tumors

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Trial Profile

A Safety, Pharmacokinetic and Efficacy Study of a y-Secretase Inhibitor, Nirogacestat (PF-03084014), in Children and Adolescents With Progressive, Surgically Unresectable Desmoid Tumors

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 15 May 2025

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At a glance

  • Drugs Nirogacestat (Primary)
  • Indications Fibroma
  • Focus Adverse reactions; Pharmacokinetics; Therapeutic Use

Most Recent Events

  • 03 Apr 2025 Planned End Date changed from 31 Mar 2025 to 30 Jun 2025.
  • 03 Apr 2025 Planned primary completion date changed from 31 Mar 2025 to 30 Jun 2025.
  • 08 Jan 2025 Planned End Date changed from 31 Dec 2024 to 31 Mar 2025.

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