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SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD): A Multi-center, Randomized, Double-Blind, Placebo-Controlled Safety and Biomarker Study of Pepinemab Anti-SEMA4D Antibody in Early-AD

Trial Profile

SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD): A Multi-center, Randomized, Double-Blind, Placebo-Controlled Safety and Biomarker Study of Pepinemab Anti-SEMA4D Antibody in Early-AD

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 05 Nov 2024

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At a glance

  • Drugs Pepinemab (Primary)
  • Indications Alzheimer's disease; Dementia
  • Focus Adverse reactions; Biomarker; Proof of concept
  • Acronyms SIGNAL-AD
  • Sponsors Vaccinex

Most Recent Events

  • 31 Oct 2024 Results presented in the Vaccinex Media Release.
  • 31 Oct 2024 According to a Vaccinex media release, company reports new positive findings for SIGNAL-AD phase 1b/2 at the Clinical Trials on Alzheimers Disease (CTAD) Conference in Madrid, Spain.
  • 24 Oct 2024 According to a Vaccinex media release, company will present promising new efficacy and safety data for its randomized, double-blind, phase 1b/2 SIGNAL-AD study of pepinemab treatment for Alzheimers disease at the Clinical Trials on Alzheimers Disease (CTAD) Conference in Madrid, on October 31, 2024.

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