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A Phase 1/2 Ascending Dose Study to Evaluate the Safety and Effects on Progranulin Levels of LY3884963 in Patients with Fronto-Temporal Dementia with Progranulin Mutations (FTD-GRN) (PROCLAIM)

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Trial Profile

A Phase 1/2 Ascending Dose Study to Evaluate the Safety and Effects on Progranulin Levels of LY3884963 in Patients with Fronto-Temporal Dementia with Progranulin Mutations (FTD-GRN) (PROCLAIM)

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 21 Mar 2025

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At a glance

  • Drugs PR 006 (Primary) ; Methylprednisolone; Prednisone; Rituximab; Sirolimus
  • Indications Dementia; Frontotemporal dementia
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms PROCLAIM
  • Sponsors Prevail Therapeutics

    • Most Recent Events

    • 18 Mar 2025 Planned End Date changed from 31 Aug 2029 to 30 Apr 2030.
    • 18 Mar 2025 Planned primary completion date changed from 31 Aug 2029 to 30 Apr 2030.
    • 21 Feb 2024 Planned number of patients changed from 23 to 35.

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