Trial Profile

Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine (HCQ) for BRAF V600E-mutant or Trametinib and HCQ for BRAF Fusion/Duplication Positive or NF1-associated Recurrent or Progressive Gliomas in Children and Young Adults

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 06 Feb 2025

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At a glance

Drugs Dabrafenib (Primary) ; Hydroxychloroquine (Primary) ; Trametinib (Primary)
Indications Glioma; Neurofibromatosis 1
Focus Adverse reactions; Pharmacokinetics; Therapeutic Use

04 Feb 2025 Status changed from recruiting to active, no longer recruiting.
27 Jan 2025 Planned End Date changed from 30 Jun 2029 to 30 Jun 2030.
27 Jan 2025 Planned primary completion date changed from 30 Aug 2026 to 31 Mar 2027.

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