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A Phase IB and Randomized Open-Label Phase II Study of Berzosertib (M6620, VX-970) in Combination With Carboplatin/Gemcitabine/Pembrolizumab in Patients With Chemotherapy-Naive Advanced Non-Small Cell Lung Cancer of Squamous Cell Histology

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Trial Profile

A Phase IB and Randomized Open-Label Phase II Study of Berzosertib (M6620, VX-970) in Combination With Carboplatin/Gemcitabine/Pembrolizumab in Patients With Chemotherapy-Naive Advanced Non-Small Cell Lung Cancer of Squamous Cell Histology

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 22 Apr 2026

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At a glance

  • Drugs Berzosertib (Primary) ; Carboplatin; Gemcitabine; Pembrolizumab
  • Indications Non-small cell lung cancer; Squamous cell cancer
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 09 Apr 2026 Planned End Date changed from 8 May 2026 to 18 Mar 2027.
  • 24 Mar 2026 Planned End Date changed from 12 Apr 2025 to 8 May 2026.
  • 13 Apr 2024 Planned End Date changed from 15 Aug 2024 to 12 Apr 2025.

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