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A Randomized, Double Blind, Prospective Trial to Evaluate Infusion-Related Reactions of Ocrelizumab in Patients with Relapsing-Remitting Multiple Sclerosis; Substudy of ESEMBLE (NCT03085810)

Trial Profile

A Randomized, Double Blind, Prospective Trial to Evaluate Infusion-Related Reactions of Ocrelizumab in Patients with Relapsing-Remitting Multiple Sclerosis; Substudy of ESEMBLE (NCT03085810)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 03 Aug 2024

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At a glance

  • Drugs Ocrelizumab (Primary)
  • Indications Multiple sclerosis
  • Focus Adverse reactions; Registrational
  • Acronyms ENSEMBLE-PLUS

Most Recent Events

  • 01 Jul 2024 Final results from full cohort of patients (n=745) from ENSEMBLE PLUS substudy, who received between one and six RDs (Interim clinical cut-off date: 4 Mar 2022) published in the Journal of Neurology
  • 27 Apr 2023 Results for Infusion-Related Reactions With Ocrelizumab, presented at the 75th Annual Meeting of the American Academy of Neurology 2023
  • 13 Oct 2021 According to a Roche media release, subgroup analysis from of three studies (SaROD, CHORDS ENSEMBLE PLUS) in Black, African-American, Hispanic and Latino populations treated with a 2 hour OCREVUS infusion are being presented at the 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) 2021.

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