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A Phase II Neoadjuvant Study of Encorafenib With Binimetinib in Patients With Resectable Locoregional Metastases From Cutaneous or Unknown Primary Melanoma (Stages III N1B/C/D)

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Trial Profile

A Phase II Neoadjuvant Study of Encorafenib With Binimetinib in Patients With Resectable Locoregional Metastases From Cutaneous or Unknown Primary Melanoma (Stages III N1B/C/D)

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 13 Jun 2025

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At a glance

  • Drugs Binimetinib (Primary) ; Encorafenib (Primary) ; F-18 fluorothymidine (Primary)
  • Indications Malignant melanoma; Skin cancer
  • Focus Diagnostic use; Therapeutic Use

Most Recent Events

  • 08 Jun 2025 Status changed from active, no longer recruiting to discontinued because of slow accrual.
  • 18 Dec 2023 Planned End Date changed from 1 Feb 2025 to 28 Feb 2025.
  • 18 Dec 2023 Planned primary completion date changed from 1 Feb 2025 to 28 Feb 2025.

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