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A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate a Switch to Doravirine/Islatravir (DOR/ISL) Once-Daily in Participants With HIV-1 Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF)

Trial Profile

A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate a Switch to Doravirine/Islatravir (DOR/ISL) Once-Daily in Participants With HIV-1 Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 04 Apr 2025

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At a glance

  • Drugs Doravirine/islatravir (Primary) ; Bictegravir/emtricitabine/tenofovir alafenamide
  • Indications HIV-1 infections
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms DOR/ISL Blinded Label Switch; ILLUMINATE SWITCH B
  • Sponsors Merck Sharp & Dohme Corp.

Most Recent Events

  • 30 Mar 2025 Status changed from suspended to completed.
  • 26 Jun 2024 This trial has been completed in Germany, according to European Clinical Trials Database record.
  • 28 Feb 2024 Planned End Date changed from 31 May 2024 to 25 Feb 2025.

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