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foresiGHt: A Multicenter, Randomized, Parallel-arm, Placebo-controlled (Double- Blind) and Active-controlled (Open-label) Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency

Trial Profile

foresiGHt: A Multicenter, Randomized, Parallel-arm, Placebo-controlled (Double- Blind) and Active-controlled (Open-label) Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 19 Feb 2026

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At a glance

  • Drugs Lonapegsomatropin (Primary) ; Somatropin
  • Indications Somatotropin deficiency
  • Focus Registrational; Therapeutic Use
  • Acronyms foresiGHt
  • Sponsors Ascendis Pharma

Most Recent Events

  • 12 Feb 2026 According to an Teijin Pharma media release, based on results from this study company has applied for manufacturing and marketing approval in Japan for lonapegsomatropin. The application has been submitted to the Pharmaceuticals and Medical Devices Agency on February 12, 2026.
  • 28 Jul 2025 According to an Ascendis Pharma media release,based on results from this trial , the U.S. Food & Drug Administration (FDA) has approved SKYTROFA for the replacement of endogenous growth hormone in adults with growth hormone deficiency (GHD).
  • 05 May 2025 According to an Ascendis Pharma media release, data from this study will be presented at the joint congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) being held May 10-13, 2025, in Copenhagen.

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