Trial Profile

A Randomized Phase II Study of Gemcitabine and Nab-Paclitaxel Compared With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan in Older Patients With Treatment Naïve Metastatic Pancreatic Cancer (GIANT)

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 18 Oct 2025

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At a glance

Drugs Fluorouracil (Primary) ; Folinic acid (Primary) ; Gemcitabine (Primary) ; Irinotecan (Primary) ; Paclitaxel (Primary)
Indications Adenocarcinoma; Pancreatic cancer
Focus Therapeutic Use
Acronyms GIANT

11 Sep 2025 Planned End Date changed from 31 Dec 2025 to 30 Dec 2026.
11 Sep 2025 Planned primary completion date changed from 31 Dec 2025 to 30 Jun 2026.
04 Jun 2024 Results(n=176) , presented at the 60th Annual Meeting of the American Society of Clinical Oncology

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