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A Two-part Phase I Study With the Antibody-drug Conjugate SYD985 in Combination With Niraparib to Evaluate Safety, Pharmacokinetics and Efficacy in Patients With HER2-expressing Locally Advanced or Metastatic Solid Tumors

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Trial Profile

A Two-part Phase I Study With the Antibody-drug Conjugate SYD985 in Combination With Niraparib to Evaluate Safety, Pharmacokinetics and Efficacy in Patients With HER2-expressing Locally Advanced or Metastatic Solid Tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 07 Jul 2023

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At a glance

  • Drugs Niraparib (Primary) ; Trastuzumab-duocarmazine (Primary)
  • Indications Advanced breast cancer; Carcinoma; Endometrial cancer; Male breast cancer; Ovarian cancer; Sarcoma; Solid tumours
  • Focus Adverse reactions
  • Sponsors Byondis

Most Recent Events

  • 03 Jul 2023 Status changed from active, no longer recruiting to completed.
  • 15 May 2023 Planned End Date changed from 1 Dec 2023 to 1 Jun 2023.
  • 23 Jan 2023 Planned End Date changed from 1 Jan 2023 to 1 Dec 2023.

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