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A Phase I, Open-label Multi-dose Pharmacokinetic and Safety Study of Oral Tazemetostat in Subjects With Moderate and Severe Hepatic Impairment With Advanced Malignancies

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Trial Profile

A Phase I, Open-label Multi-dose Pharmacokinetic and Safety Study of Oral Tazemetostat in Subjects With Moderate and Severe Hepatic Impairment With Advanced Malignancies

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 07 May 2026

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At a glance

  • Drugs Tazemetostat (Primary)
  • Indications Haematological malignancies; Solid tumours
  • Focus Pharmacokinetics
  • Sponsors Epizyme

Most Recent Events

  • 29 Jan 2026 Planned End Date changed from 30 Apr 2026 to 12 Mar 2026.
  • 29 Jan 2026 Planned primary completion date changed from 31 Mar 2026 to 12 Mar 2026.
  • 29 Jan 2026 Planned End Date changed from 25 Mar 2026 to 30 Apr 2026.

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