Trial Profile

A Phase Ib Study of Ipatasertib, an AKT Inhibitor, in Combination With Pertuzumab Plus Trastuzumab in Patients With PI3KCA-mutant, HER2-positive Locally Advanced or Metastatic Breast Cancer

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 20 Apr 2026

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At a glance

Drugs Ipatasertib (Primary) ; Pertuzumab (Primary) ; Trastuzumab (Primary) ; Trastuzumab (Primary)
Indications Adenocarcinoma; Advanced breast cancer; HER2 positive breast cancer; Male breast cancer
Focus Adverse reactions
Acronyms IPATHER

Most Recent Events

16 Mar 2026 Status changed from recruiting to completed.
17 Apr 2023 Planned number of patients changed from 25 to 15.
17 Apr 2023 Planned End Date changed from 12 Aug 2024 to 25 Aug 2025.

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