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Randomized, Evaluation of Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement

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Trial Profile

Randomized, Evaluation of Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement

Status: Recruiting
Phase of Trial: Phase IV

Latest Information Update: 08 Jul 2026

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At a glance

  • Drugs Apixaban (Primary) ; Rivaroxaban (Primary) ; Warfarin
  • Indications Thromboembolism
  • Focus Therapeutic Use
  • Acronyms RENOVATE

Most Recent Events

  • 29 Dec 2025 Planned End Date changed from 30 Jun 2026 to 30 Dec 2028.
  • 29 Dec 2025 Planned primary completion date changed from 31 Dec 2025 to 31 Dec 2027.
  • 13 Jun 2025 Planned End Date changed from 30 Jun 2025 to 30 Jun 2026.

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