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A Randomised, Multicentre, Double-blind, Placebo-controlled, Phase III Study of First-line Carboplatin and Paclitaxel in Combination With Durvalumab, Followed by Maintenance Durvalumab With or Without Olaparib in Patients With Newly Diagnosed Advanced or Recurrent Endometrial Cancer (DUO-E)

Trial Profile

A Randomised, Multicentre, Double-blind, Placebo-controlled, Phase III Study of First-line Carboplatin and Paclitaxel in Combination With Durvalumab, Followed by Maintenance Durvalumab With or Without Olaparib in Patients With Newly Diagnosed Advanced or Recurrent Endometrial Cancer (DUO-E)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 13 Feb 2025

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At a glance

  • Drugs Durvalumab (Primary) ; Olaparib (Primary) ; Carboplatin; Paclitaxel
  • Indications Carcinoma; Endometrial cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms DUO-E
  • Sponsors AstraZeneca; AstraZeneca AB

Most Recent Events

  • 20 Nov 2024 Planned End Date changed from 14 Aug 2027 to 1 Apr 2027.
  • 03 Sep 2024 According to an AstraZeneca media release, clinical data from this trial will be presented at the European Society for Medical Oncology (ESMO) Congress, September 13 to 17, 2024.
  • 14 Aug 2024 Results presented in an Astrazeneca media release.

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