Trial Profile

A Phase 1a/1b Open-Label Dose Escalation and Expansion Study of Bcl-2 Inhibitor BGB-11417 in Patients With Mature B-Cell Malignancies

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 09 Apr 2026

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At a glance

Drugs Obinutuzumab (Primary) ; Sonrotoclax (Primary) ; Zanubrutinib (Primary)
Indications Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
Focus Adverse reactions; First in man
Sponsors BeOne Medicines

Most Recent Events

27 Mar 2026 Planned End Date changed from 30 Aug 2027 to 31 May 2027.
27 Mar 2026 Planned primary completion date changed from 30 Aug 2027 to 31 May 2027.
07 Dec 2025 According to a BeOne Medicines media release, data from the trial were presented at the 67th American Society of Hematology (ASH) Annual Meeting & Exposition in Orlando, Florida.

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