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A Phase I clinical study of I-131-Apamistamab as conditioning prior to treatment with a commercial CAR-T therapy

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A Phase I clinical study of I-131-Apamistamab as conditioning prior to treatment with a commercial CAR-T therapy

Status: Planning
Phase of Trial: Phase I

Latest Information Update: 20 Aug 2024

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At a glance

  • Drugs CAR-T cell therapies (Primary) ; I-131-Apamistamab (Primary)
  • Indications Acute myeloid leukaemia; Myelodysplastic syndromes; Precursor B-cell lymphoblastic leukaemia-lymphoma
  • Focus Therapeutic Use

    • Most Recent Events

    • 01 Aug 2024 According to an Actinium Pharmaceuticals media release, IND applications have been cleared by the FDA for the commercial CAR-T Phase 1 trial and patient enrollment is expected to commence.
    • 26 Mar 2024 According to an Actinium Pharmaceuticals media release, the University of Texas Southwestern Medical Center (UT Southwestern) will lead a clinical trial studying Actinium's Iomab-ACT, a targeted radiotherapy conditioning agent prior to patients receiving an FDA approved commercial CAR T-cell therapy. UT Southwestern will start recruiting patients following FDA's review and clearance of the study.
    • 25 Feb 2020 New trial record

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