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BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 2 (BLAST MRD AML-2): A Randomized Phase 2 Study of the Venetoclax, Azacitidine, and Pembrolizumab (VAP) Versus Venetoclax and Azacitidine as First Line Therapy in Older Patients With Acute Myeloid Leukemia (AML) Who Are Ineligible or Who Refuse Intensive Chemotherapy

Trial Profile

BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 2 (BLAST MRD AML-2): A Randomized Phase 2 Study of the Venetoclax, Azacitidine, and Pembrolizumab (VAP) Versus Venetoclax and Azacitidine as First Line Therapy in Older Patients With Acute Myeloid Leukemia (AML) Who Are Ineligible or Who Refuse Intensive Chemotherapy

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 23 Apr 2025

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At a glance

  • Drugs Azacitidine (Primary) ; Azacitidine (Primary) ; Pembrolizumab (Primary) ; Venetoclax (Primary)
  • Indications Acute myeloid leukaemia
  • Focus Therapeutic Use
  • Acronyms BLAST AML-2; BLAST MRD AML-2

Most Recent Events

  • 03 Feb 2025 Planned End Date changed from 1 Aug 2025 to 30 Jan 2026.
  • 19 Aug 2024 Planned End Date changed from 1 Aug 2024 to 1 Aug 2025.
  • 19 Aug 2024 Planned primary completion date changed from 1 Aug 2024 to 1 Aug 2025.

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