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A Single-Arm, Open-Label, Phase 1/2 Study Evaluating the Safety, Efficacy, and Cellular Kinetics/Pharmacodynamics of ALLO-501A, an Anti-CD19 Allogeneic CAR T Cell Therapy, and ALLO-647, an Anti-CD52 Monoclonal Antibody, in Subjects With Relapsed/Refractory Large B-Cell Lymphoma (LBCL)

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Trial Profile

A Single-Arm, Open-Label, Phase 1/2 Study Evaluating the Safety, Efficacy, and Cellular Kinetics/Pharmacodynamics of ALLO-501A, an Anti-CD19 Allogeneic CAR T Cell Therapy, and ALLO-647, an Anti-CD52 Monoclonal Antibody, in Subjects With Relapsed/Refractory Large B-Cell Lymphoma (LBCL)

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 18 Mar 2026

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At a glance

  • Drugs ALLO 647 (Primary) ; Cemacabtagene ansegedleucel (Primary) ; Cyclophosphamide; Famotidine; Fludarabine; Hydrocortisone; Letermovir; Loratadine; Paracetamol; Promethazine; Tocilizumab
  • Indications B-cell lymphoma; Chronic lymphocytic leukaemia; Non-Hodgkin's lymphoma
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms ALPHA2
  • Sponsors Allogene Therapeutics

Most Recent Events

  • 04 Mar 2026 Planned primary completion date changed from 1 Aug 2025 to 1 Feb 2029.
  • 13 Feb 2025 Results presented in the Allogene Therapeutics Media Release.
  • 13 Feb 2025 According to an Allogene Therapeutics media release, durable response data from Phase 1 ALPHA and ALPHA2 clinical studies of cemacabtagene ansegedleucel in relapsed/refractory large B-cell lymphoma published as a Rapid Communication in the Journal of Clinical Oncology.

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