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A Prospective, Randomized, Three-period Crossover, Interaction Study to Evaluate the Pharmacokinetics of Doravirine and Tenofovir Disoproxil Fumarate Co-administered With Cross-sex Hormonal Therapy in Adult HIV-negative Transgender Women

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Trial Profile

A Prospective, Randomized, Three-period Crossover, Interaction Study to Evaluate the Pharmacokinetics of Doravirine and Tenofovir Disoproxil Fumarate Co-administered With Cross-sex Hormonal Therapy in Adult HIV-negative Transgender Women

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 02 Apr 2025

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At a glance

  • Drugs Doravirine/lamivudine/tenofovir disoproxil fumarate (Primary) ; Estradiol; Spironolactone
  • Indications HIV infections
  • Focus Pharmacokinetics

    • Most Recent Events

    • 01 Feb 2023 Status changed from active, no longer recruiting to completed.
    • 18 Oct 2022 Planned End Date changed from 30 Jul 2022 to 30 Dec 2022.
    • 18 Oct 2022 Planned primary completion date changed from 1 Jun 2022 to 1 Nov 2022.

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