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An Open-Label, Single-Dose Study to Evaluate the Pharmacokinetics of Islatravir (MK-8591) in Subjects With Severe Renal Impairment

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Trial Profile

An Open-Label, Single-Dose Study to Evaluate the Pharmacokinetics of Islatravir (MK-8591) in Subjects With Severe Renal Impairment

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 11 Nov 2022

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At a glance

  • Drugs Islatravir (Primary)
  • Indications HIV infections; HIV-1 infections
  • Focus Pharmacokinetics
  • Sponsors Merck Sharp & Dohme Corp.

Most Recent Events

  • 08 Nov 2022 Results assessing he impact of renal impairment on the pharmacokinetics of islatravir in individuals with severe renal insufficiency, published in the Antimicrobial Agents and Chemotherapy.
  • 21 Jul 2021 Results assessing safety and tolerability in individuals with severe renal insufficiency and healthy matched control presented at the 11th International AIDS Society Conference on HIV Science
  • 28 Oct 2020 Status changed from active, no longer recruiting to completed.

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