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A Randomized, Double-Blinded, Placebo-Controlled, Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending and Multiple Doses of ION-682884 in Healthy Japanese Participants

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Trial Profile

A Randomized, Double-Blinded, Placebo-Controlled, Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending and Multiple Doses of ION-682884 in Healthy Japanese Participants

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 29 Jul 2022

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At a glance

  • Drugs Eplontersen (Primary)
  • Indications Transthyretin-related hereditary amyloidosis
  • Focus Adverse reactions
  • Sponsors Ionis Pharmaceuticals

Most Recent Events

  • 22 Jul 2022 Results from NCT03728634, NCT04302064, developing a population pharmacokinetic/pharmacodynamic model for eplontersen and to evaluate the impact of covariates on exposure and response, published in the British Journal of Clinical Pharmacology
  • 02 Feb 2021 Status changed from recruiting to completed.
  • 06 Apr 2020 Planned End Date changed from 1 Jun 2020 to 1 Jul 2020.

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