Viral load change
description: Viral load change (log10 viral load assessed by reverse transcription-PCR) during hospital day 3, 5, 7, 10, 14, 18)
time_frame: hospital day 3, 5, 7, 10, 14, 18
Time to clinical improvement (TTCI)
description: Time to clinical improvement (TTCI) is defined as the time to normalization of fever, respiratory rate, and oxygen saturation, and alleviation of cough within at least 72 hours
time_frame: up to 28 days
Percentage of progression to supplemental oxygen requirement by day 7
description: Percentage of progression to supplemental oxygen requirement by day 7
time_frame: hospital day 7
Time to NEWS2 (National Early Warning Score 2) of 3 or more maintained for 24 hours by day 7
description: Time to NEWS2 (National Early Warning Score 2) of 3 or more maintained for 24 hours by day 7
time_frame: hospital day 7
Time to clinical failure, defined as the time to death, mechanical ventilation, or ICU admission
description: Time to clinical failure, defined as the time to death, mechanical ventilation, or ICU admission
time_frame: up to 28 days
Rate of switch to Lopinavir/ritonavir or hydroxychloroquine by day 7
description: Rate of switch to Lopinavir/ritonavir or hydroxychloroquine by day 7
time_frame: hospital day 7
adverse effects
description: Safety and tolerability, as assessed by adverse effects
time_frame: up to 28 days
Concentration of Lopinavir/ritonavir and hydroxychloroquine
description: Concentration of Lopinavir/ritonavir and hydroxychloroquine
time_frame: 1, 2, 4, 5, 12 hours after taking intervention medicine [1]
