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A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02B

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Trial Profile

A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02B

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 29 Mar 2025

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At a glance

  • Drugs Favezelimab/pembrolizumab (Primary) ; Lenvatinib (Primary) ; Pembrolizumab (Primary) ; Pembrolizumab/Quavonlimab (Primary) ; Quavonlimab (Primary) ; Vibostolimab (Primary) ; Tretinoin
  • Indications Malignant melanoma; Skin cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms KEYMAKER-U02; KEYNOTE-U02; Substudy 02B
  • Sponsors Merck Sharp & Dohme; Merck Sharp & Dohme Corp.

    • Most Recent Events

    • 12 Sep 2023 Planned number of patients changed from 405 to 510.
    • 12 Sep 2023 Planned number of patients changed from 405 to 510.
    • 21 Sep 2021 trial design presented at the 46th European Society for Medical Oncology Congress

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