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A Phase I Study of Vorinostat in Combination With Vincristine, Irinotecan, and Temozolomide in Children, Adolescents, and Young Adults With Relapsed or Refractory Solid Tumors and CNS Malignancies

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Trial Profile

A Phase I Study of Vorinostat in Combination With Vincristine, Irinotecan, and Temozolomide in Children, Adolescents, and Young Adults With Relapsed or Refractory Solid Tumors and CNS Malignancies

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 07 May 2026

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At a glance

  • Drugs Irinotecan (Primary) ; Temozolomide (Primary) ; Vincristine (Primary) ; Vorinostat (Primary) ; Cefixime
  • Indications CNS cancer; Solid tumours
  • Focus Adverse reactions

Most Recent Events

  • 15 Apr 2026 Planned End Date changed from 31 Dec 2024 to 31 Dec 2027.
  • 15 Apr 2026 Planned primary completion date changed from 31 Dec 2023 to 31 Dec 2026.
  • 24 Oct 2022 Planned End Date changed from 17 Dec 2022 to 31 Dec 2024.

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