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A Phase I/Ib Trial of the CDK4/6 Antagonist Ribociclib And The HDAC Inhibitor Belinostat In Patients With Metastatic Triple Negative Breast Cancer And Recurrent Ovarian Cancer With Response Prediction By Genomics (CHARGE)

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Trial Profile

A Phase I/Ib Trial of the CDK4/6 Antagonist Ribociclib And The HDAC Inhibitor Belinostat In Patients With Metastatic Triple Negative Breast Cancer And Recurrent Ovarian Cancer With Response Prediction By Genomics (CHARGE)

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 14 Mar 2025

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At a glance

  • Drugs Belinostat (Primary) ; Ribociclib (Primary)
  • Indications Advanced breast cancer; Carcinoma; HER2 negative breast cancer; Male breast cancer; Ovarian cancer; Triple negative breast cancer
  • Focus Adverse reactions
  • Acronyms CHARGE

    • Most Recent Events

    • 04 May 2023 Planned End Date changed from 1 Aug 2025 to 1 Aug 2026.
    • 04 May 2023 Planned primary completion date changed from 1 Aug 2023 to 1 Aug 2024.
    • 30 Oct 2020 Status changed from not yet recruiting to recruiting.

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