Patient Inclusion Criteria

1. Has COVID-19 disease, defined by having one or more of the following new symptoms and signs (within 7 days): - Fevers OR - At least one of the following symptoms: cough, shortness of breath, respiratory rate ≥ 20, radiographic evidence of pneumonia OR - Anosmia OR - other clinical symptoms or signs of COVID-19 that are not otherwise explained by comorbidities or co-diagnoses 2. PCR+ test for SARS-CoV-2. 3. Has new signs or symptoms of COVID-19 that began ≤7 days of anticipated first dose of study drug. 4. Persons ≥18 years old. 5. at the time of first dose. 5. ≥18 years old. 6. Is willing and able to comply with all study procedures including providing informed consent, collection of virology samples, and any safety tests that are not included as part of standard of care (SOC). 7. Is willing and able to take oral medications, and is anticipated to be able to take the full course of 5 days of study drug. Pregnancy and Contraception: In nonclinical developmental and reproductive toxicity studies, developmental toxicity including malformation was observed in fetuses from pregnant animals dosed with EIDD-2801 (MK 4482). Therefore, treatment with EIDD-2801 is contraindicated in women who are pregnant or nursing and in the male partners of women who are pregnant. Extreme care must be taken to avoid pregnancy during the study and for 4 days after completion of EIDD 2801 dosing in female participants and for 4 days after completion of EIDD-2801 dosing in female partners of male participants. 8. A female participant is eligible to participate if she is not pregnant or breastfeeding and at least one of the following conditions applies: - Is not a woman of childbearing potential (WOCBP) OR - Is a WOCBP and using a contraceptive method that is highly effective (a low user dependency method OR a user-dependent method in combination with a barrier method), or be abstinent from heterosexual intercourse as their preferred and usual lifestyle (abstinent on a long-term and persistent basis), as described in Appendix 2 during the intervention period and for at least 4 days after the last dose of study intervention. The investigator should evaluate the potential for contraceptive method failure (ie, noncompliance, recently initiated) in relationship to the first dose of study intervention. - A WOCBP must have a negative highly sensitive pregnancy test (serum test is required) within 24 hours before the first dose of study intervention. - Additional requirements for pregnancy testing during and after study intervention are located in Section 4.4. - The investigator is responsible for review of medical history, menstrual history, and recent sexual activity to decrease the risk for inclusion of a woman with an early undetected pregnancy. - Contraceptive use by women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. - Given the elevated risk of venous thrombotic events in patients hospitalized with COVID 19 (Benson et al 2020; Spratt et al 2020), estrogen-containing contraceptives must not be started to fulfill the contraceptive requirement of this study at any time during participant's hospitalization. If contraceptives are interrupted as standard of care management of COVID-19 patients and resumed at a later time point, such as at hospital discharge, then abstinence must be practiced for the defined period of back-up contraception per the contraceptive product labeling. After this period, contraceptive use must adhere to Appendix 2. 9. Male participants are eligible to participate if they agree to the following during the intervention period and for at least 4 days after the last dose of study intervention: - Be abstinent from heterosexual intercourse as their preferred and usual lifestyle (abstinent on a long term and persistent basis) and agree to remain abstinent OR - Must agree to use contraception unless confirmed to be azoospermic (vasectomized or secondary to medical cause [Appendix 2]) as detailed below: Agree to use a male condom plus partner use of an additional contraceptive method when having penile-vaginal intercourse with a WOCBP who is not currently pregnant. Note: Men with a pregnant or breastfeeding partner must agree to remain abstinent from penile-vaginal intercourse or use a male condom during each episode of penile-vaginal penetration. • Contraceptive use by men should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.

Patient Exclusion Criteria

1. Is anticipated to require ICU admission for mechanical ventilation within 24 hours of enrollment. 2. Requires more than 6 liters/minute of oxygen to maintain O2 saturation above 95% 3. Is not expected to survive longer than 24 hours. 4. Has a platelet count less than 100,000/µL, hemoglobin less than 9 g/dL, or has a disorder of the hematologic system including anemic disorder or other blood dyscrasia, cancer of the hematologic system, history of bone marrow transplant, or other significant hematologic disease. 5. Women who are pregnant or breastfeeding. 6. Is experiencing DAIDS AE grading scale grade 4 baseline medical conditions or laboratory abnormalities.. 7. Has received a vaccine for COVID-19 prior to enrollment, or plans to receive a vaccine for COVID-19 before the end-of-study visit. 8. Has received an experimental antiviral treatment for COVID-19 prior to enrollment. 9. Has received convalescent plasma or other monoclonal antibodies prior to enrollment.. 10. Is participating in another clinical study that involves pharmacologic intervention or has participated in another study within 30 days of 5 half-lives of the investigational agent (observational study participation is permitted). 11. In the opinion of the investigator, has end-organ disease as a result of relevant comorbidities: chronic kidney disease (reduced glomerular filtration rate (GFR) <30 mL/min by the Modification of Diet in Renal Disease (MDRD) study equation prior to COVID-19 symptom onset), decompensated chronic liver disease or cirrhosis, decompensated congestive heart failure, active peripheral vascular disease including active diabetic ulcers, chronic pulmonary disease prior to COVID-19 symptom onset requiring bilevel positive airway pressure (BiPAP) or >4 L/min supplemental oxygen at baseline; if using ≤4 L/min supplemental oxygen at baseline, consultation with and approval of the sponsor is required prior to enrollment. 12. Has a diagnosis of cancer that is not in remission. Noninvasive cancers, such as basal and squamous cell carcinoma or history of in situ tumors are allowed at the discretion of the investigator after discussion with the sponsor. 13. Has received an organ transplantation. 14. Has received a bone marrow transplantation. 15. Has been on immunosuppressive medications within one month prior to enrollment. 16. Has any condition that would, in the opinion of the investigator, put the participant at increased risk for participation in a clinical trial. 17. Has known active hepatitis C (HCV RNA positive), active hepatitis B (hepatitis B surface antigen positive), or HIV (ELISA and confirmatory Western blotting). New screening tests not required. 18. Is currently taking nucleos(t)ide analogues for HIV or Hepatitis B, or for their prevention, within 30 days of study enrollment. 19. Is currently taking systemic corticosteroids other than replacement doses, or for treatment of COVID-19. 20. Has a Body Mass Index (BMI) >50 kg/m2. 21. Is anticipated to require surgery within 48 hours after hospital admission. 22. Is anticipated to have a nothing per mouth (NPO) order placed within 48 hours after hospital admission that is expected to last for > 24 hours.