Trial Profile

NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of LOXO-292 in Patients With Tumors Harboring RET Gene Alterations

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 30 Jul 2025

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At a glance

Drugs Selpercatinib (Primary)
Indications CNS cancer; Ependymoma; Ewing's sarcoma; Germ cell and embryonal neoplasms; Germ cell cancer; Glioma; Hepatoblastoma; Langerhans cell histiocytosis; Lymphoma; Medulloblastoma; Neuroblastoma; Non-Hodgkin's lymphoma; Osteosarcoma; Primitive neuroectodermal tumours; Rhabdoid tumour; Rhabdomyosarcoma; Soft tissue sarcoma; Solid tumours; Wilms' tumour
Focus Therapeutic Use
Acronyms Pediatric MATCH Treatment

10 Oct 2024 Planned End Date changed from 30 Sep 2024 to 8 Oct 2025.
11 Jul 2024 Planned End Date changed from 30 Sep 2027 to 30 Sep 2024.
11 Jul 2024 Planned primary completion date changed from 30 Sep 2027 to 30 Sep 2024.

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