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Phase I, First-in-human, Open-label, Dose Escalation Trial to Evaluate Safety, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of BNT152+153 in Patients With Solid Tumors

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Phase I, First-in-human, Open-label, Dose Escalation Trial to Evaluate Safety, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of BNT152+153 in Patients With Solid Tumors

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 24 Mar 2025

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At a glance

  • Drugs BNT 152 (Primary) ; BNT 153 (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors BioNTech

    • Most Recent Events

    • 21 Mar 2025 Status changed from recruiting to active, no longer recruiting.
    • 25 Jul 2023 Number of treatment arms have been increased from 2 to 6 by the addition of 4 arms for Part 2 namely Experimental: Part 2 - BNT152+153 - biomarker cohort and Part 2A, 2B and 2C.
    • 25 Jul 2023 Planned number of patients changed from 112 to 170.

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