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Phase 1/2 Study of the Safety, Pharmacokinetics, and Preliminary Clinical Activity of BT7480 in Patients With Nectin-4 Associated Advanced Malignancies

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Trial Profile

Phase 1/2 Study of the Safety, Pharmacokinetics, and Preliminary Clinical Activity of BT7480 in Patients With Nectin-4 Associated Advanced Malignancies

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 06 Feb 2025

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At a glance

  • Drugs BT 7480 (Primary) ; Nivolumab (Primary)
  • Indications Advanced breast cancer; Anal cancer; Carcinoma; Cervical cancer; Gastric cancer; Head and neck cancer; Male breast cancer; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Bicycle Therapeutics

    • Most Recent Events

    • 04 Feb 2025 Status changed from recruiting to active, no longer recruiting.
    • 13 Jan 2025 According to a Bicycle Therapeutics media release, company to report combination data for BT7480 plus nivolumab in 4Q 2025.
    • 31 Oct 2024 According to a Bicycle Therapeutics media release, initial data were presented at the European Society for Medical Oncology Congress 2024.

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