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A Phase 2 Study of Avutometinib (VS-6766) (Dual RAF/MEK Inhibitor) Alone and in Combination with Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

Trial Profile

A Phase 2 Study of Avutometinib (VS-6766) (Dual RAF/MEK Inhibitor) Alone and in Combination with Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 17 Apr 2026

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At a glance

  • Drugs Avutometinib (Primary) ; Defactinib (Primary)
  • Indications Adenocarcinoma; Ovarian cancer; Peritoneal cancer
  • Focus Proof of concept; Registrational; Therapeutic Use
  • Acronyms RAMP 201
  • Sponsors Verastem Oncology

Most Recent Events

  • 10 Apr 2026 Results published in the Media Release
  • 10 Apr 2026 According to a Verastem Oncology media release, data from this study will be presented today during an oral plenary session at the Society of Gynecologic Oncology (SGO) 2026 Annual Meeting on Women's Cancers taking place in San Juan, Puerto Rico, April 10-13, 2026.
  • 17 Mar 2026 According to a Verastem Oncology media release, company announced it will present new long-term data from the Phase 2 RAMP 201 clinical trial at the Society of Gynecologic Oncology (SGO) 2026 Annual Meeting on Women's Cancers. will also be shared at the meeting being held on April 10-13, 2026, in San Juan, Puerto Rico.

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