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A Phase 2 Study of Avutometinib (VS-6766) (Dual RAF/MEK Inhibitor) Alone and in Combination with Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

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Trial Profile

A Phase 2 Study of Avutometinib (VS-6766) (Dual RAF/MEK Inhibitor) Alone and in Combination with Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 23 Jul 2025

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At a glance

  • Drugs Avutometinib (Primary) ; Defactinib (Primary)
  • Indications Adenocarcinoma; Ovarian cancer; Peritoneal cancer
  • Focus Proof of concept; Registrational; Therapeutic Use
  • Acronyms RAMP 201
  • Sponsors Verastem Oncology

Most Recent Events

  • 11 Jul 2025 According to a Verastem Oncology media release, the RAMP 201 study results were initially presented in an oral plenary session at the International Gynecologic Cancer Society (IGCS) Annual Meeting in October 2024.
  • 11 Jul 2025 According to a Verastem Oncology media release, the company will submit the RAMP 201 publication and the recent publication of the FRAME study to the National Comprehensive Cancer Network (NCCN) in support of its consideration of inclusion of the KRAS wild-type population evaluated in these trials in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines).
  • 11 Jul 2025 According to a Verastem Oncology media release, company announced that the primary analysis of the Phase 2 RAMP 201 clinical trial was published online in the Journal of Clinical Oncology (JCO).

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