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A Phase 2 Study of Avutometinib (VS-6766) (Dual RAF/MEK Inhibitor) Alone and in Combination with Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

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Trial Profile

A Phase 2 Study of Avutometinib (VS-6766) (Dual RAF/MEK Inhibitor) Alone and in Combination with Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 22 Jun 2025

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At a glance

  • Drugs Avutometinib (Primary) ; Defactinib (Primary)
  • Indications Adenocarcinoma; Ovarian cancer; Peritoneal cancer
  • Focus Proof of concept; Registrational; Therapeutic Use
  • Acronyms RAMP 201
  • Sponsors Verastem Oncology

Most Recent Events

  • 08 May 2025 According to a Verastem Oncology media release, based on results form this trial, the U.S. Food and Drug Administration (FDA) has approved AVMAPKI FAKZYNJA CO-PACK (avutometinib capsules; defactinib tablets) for the treatment of adult patients with KRAS-mutated recurrent low-grade serous ovarian cancer (LGSOC) who received prior systemic therapy.
  • 20 Feb 2025 According to a Verastem Oncology media release, company announced multiple oral and poster presentations, including an oral presentation of additional analyses from this trial at the Society of Gynecologic Oncology 2025 Annual Meeting on Womens Cancer, to be held on March 14-17 in Seattle, Washington. Verastem will also have an exhibition booth 622 at the meeting where it will be available to discuss its ongoing cancer research.
  • 23 Jan 2025 According to a Verastem Oncology media release, company will submit submit RAMP 201 primary analysis publication for NCCN consideration in H1 2025. Company will present additional analyses from the RAMP 201 trial at a medical meeting in Q1 2025.

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