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A PHASE 3B RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, ACTIVE CONTROLLED MULTI-CENTER STUDY ASSESSING THE EFFICACY AND SAFETY OF ABROCITINIB COMPARED WITH DUPILUMAB IN ADULT PARTICIPANTS ON BACKGROUND TOPICAL THERAPY WITH MODERATE TO SEVERE ATOPIC DERMATITIS

Trial Profile

A PHASE 3B RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, ACTIVE CONTROLLED MULTI-CENTER STUDY ASSESSING THE EFFICACY AND SAFETY OF ABROCITINIB COMPARED WITH DUPILUMAB IN ADULT PARTICIPANTS ON BACKGROUND TOPICAL THERAPY WITH MODERATE TO SEVERE ATOPIC DERMATITIS

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 14 Sep 2023

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At a glance

  • Drugs Abrocitinib (Primary) ; Dupilumab
  • Indications Atopic dermatitis
  • Focus Registrational; Therapeutic Use
  • Acronyms JADE DARE
  • Sponsors Pfizer
  • Most Recent Events

    • 21 Mar 2023 Results of post hoc Pooled Analysis of JADE COMPARE and JADE DARE assessing efficacy and safety of abrocitinib and dupilumab in patients with moderate-to-severe AD, with or without comorbid asthma or allergic rhinitis. presented at the American Academy of Dermatology annual Meeting 2023
    • 27 Feb 2023 Results of pooled post hoc analysis of two phase 3, randomized trials (n=1195, JADE COMPARE, NCT03720470; JADE DARE, NCT04345367) assessing the effects of abrocitinib and dupilumab on eosinophilia in patients with moderate-to-severe AD, with or without comorbid asthma or allergic rhinitis.presented at the 2023 Annual Meeting of the American Academy of Allergy, Asthma and Immunology
    • 30 Aug 2021 According to a Pfizer media release, full results from this study will be submitted for presentation at a future scientific meeting and publication in a medical journal and at the appropriate time, the company intends to share these data with the U.S. Food and Drug Administration (FDA) and other regulatory agencies around the world reviewing submissions for abrocitinib.

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