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A Phase 1 Dose Finding Study of the gFOLFOXIRITAX Regimen Using UGT1A1 Genotype-directed Irinotecan With Fluorouracil, Leucovorin, Oxaliplatin and Taxotere in Patients With Untreated Advanced Upper Gastrointestinal Adenocarcinomas: The I-FLOAT Study

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Trial Profile

A Phase 1 Dose Finding Study of the gFOLFOXIRITAX Regimen Using UGT1A1 Genotype-directed Irinotecan With Fluorouracil, Leucovorin, Oxaliplatin and Taxotere in Patients With Untreated Advanced Upper Gastrointestinal Adenocarcinomas: The I-FLOAT Study

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 30 Aug 2023

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At a glance

  • Drugs Docetaxel (Primary) ; Fluorouracil (Primary) ; Folinic acid (Primary) ; Irinotecan (Primary) ; Oxaliplatin (Primary)
  • Indications Adenocarcinoma; Carcinoma; Cholangiocarcinoma; Gallbladder cancer; Gastric cancer; Gastrointestinal cancer; Oesophageal cancer; Pancreatic cancer
  • Focus Adverse reactions
  • Acronyms I-FLOAT

    • Most Recent Events

    • 25 Aug 2023 Planned primary completion date changed from 1 Jun 2023 to 1 Jun 2025.
    • 06 Jun 2023 Results (Data from 6/30/22 to 1/1/23, n=27) presented at the 59th Annual Meeting of the American Society of Clinical Oncology.
    • 26 Apr 2023 Planned primary completion date changed from 1 Jun 2022 to 1 Jun 2023.

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