Trial Profile

A Phase I Clinical Trial of Regorafenib, Nivolumab, and Ipilimumab in Advanced Chemotherapy Resistant Metastatic MSS Colorectal Cancer

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 18 Jun 2025

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At a glance

Drugs Ipilimumab (Primary) ; Nivolumab (Primary) ; Regorafenib (Primary)
Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Liver metastases; Rectal cancer
Focus Adverse reactions

Most Recent Events

30 Apr 2025 Results assessing identify predictive biomarkers and elucidate the immunological mechanisms associated with response and resistance to RIN therapy in MSS mCRC patients, presented at the 116th Annual Meeting of the American Association for Cancer Research.
29 Jan 2025 Planned End Date changed from 30 Dec 2024 to 13 Sep 2025.
29 Jan 2025 Planned primary completion date changed from 30 Dec 2024 to 13 Sep 2025.

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