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A Multicentre, Open-Label, Single Ascending Dose, Dose-Ranging, Phase I/IIa Study to Evaluate the Safety and Tolerability of an Autologous Antigen-Specific Chimeric Antigen Receptor T Regulatory Cell Therapy (TX200-TR101) in Living Donor Renal Transplant Recipients

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Trial Profile

A Multicentre, Open-Label, Single Ascending Dose, Dose-Ranging, Phase I/IIa Study to Evaluate the Safety and Tolerability of an Autologous Antigen-Specific Chimeric Antigen Receptor T Regulatory Cell Therapy (TX200-TR101) in Living Donor Renal Transplant Recipients

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 14 Feb 2025

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At a glance

  • Drugs TX-200 (Primary)
  • Indications Renal transplant rejection
  • Focus Adverse reactions; First in man
  • Acronyms STeadfast
  • Sponsors Sangamo Therapeutics

Most Recent Events

  • 16 Aug 2024 Planned End Date changed from 4 Mar 2026 to 29 Oct 2025.
  • 24 Apr 2024 This trial has been completed in Germany, according to European Clinical Trials Database record.
  • 24 Apr 2024 This trial has been completed in Germany, according to European Clinical Trials Database record.

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