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A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Ruxolitinib in Participants With COVID-19-Associated ARDS Who Require Mechanical Ventilation (RUXCOVID-DEVENT)

Trial Profile

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Ruxolitinib in Participants With COVID-19-Associated ARDS Who Require Mechanical Ventilation (RUXCOVID-DEVENT)

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 05 Dec 2022

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At a glance

  • Drugs Ruxolitinib (Primary) ; Ruxolitinib (Primary)
  • Indications SARS-CoV-2 acute respiratory disease
  • Focus Registrational; Therapeutic Use
  • Acronyms 369-DEVENT; RUXCOVID-DEVENT
  • Sponsors Incyte Corporation
  • Most Recent Events

    • 01 Dec 2022 Results assessing the safety and efficacy of the Janus kinase (JAK)1/JAK2 inhibitor ruxolitinib in COVID-19-associated acute respiratory distress syndrome requiring mechanical ventilation published in the Critical Care Medicine
    • 18 Mar 2021 According to an Incyte Corporation media release, the company will discuss the results of the DEVENT study with regulatory authorities in the United States.
    • 18 Mar 2021 Primary endpoint has not been met. (Proportion of participants who have died due to any cause), according to an Incyte Corporation media release.

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