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A Phase 1/2 Open Label, Dose Escalation and Expansion Study of MDNA11, IL-2 Superkine, Administered Alone or in Combination With Immune Checkpoint Inhibitor in Patients With Advanced Solid Tumors

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Trial Profile

A Phase 1/2 Open Label, Dose Escalation and Expansion Study of MDNA11, IL-2 Superkine, Administered Alone or in Combination With Immune Checkpoint Inhibitor in Patients With Advanced Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 06 May 2025

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At a glance

  • Drugs MDNA 11 (Primary) ; Pembrolizumab (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Basal cell cancer; Biliary cancer; Bladder cancer; Cervical cancer; Cholangiocarcinoma; Colorectal cancer; Gallbladder cancer; Gastric cancer; Head and neck cancer; Malignant melanoma; Merkel cell carcinoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Pancreatic ductal carcinoma; Renal cell carcinoma; Sarcoma; Solid tumours; Squamous cell cancer; Uterine cancer
  • Focus Adverse reactions; First in man
  • Acronyms ABILITY; ABILITY-1
  • Sponsors Medicenna Therapeutics

Most Recent Events

  • 28 Apr 2025 Results presented in the Medicenna Therapeutics media release.
  • 25 Feb 2025 According to a Medicenna Therapeutics media release, the enrollment completion of monotherapy expansion and combination dose escalation is anticipated in mid 2025; initiation of combination dose expansion is also expected in mid 2025, and the addition of several new tumor types will be done in this study.
  • 25 Feb 2025 According to a Medicenna Therapeutics media release, the safety and efficacy results of MDNA11 as a monotherapy and in combination with KEYTRUDA will be presented at medical conferences in H1 2025.

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