Trial Profile

A pharmacodynamic drug-drug interaction (DDI), one way cross-over study between givosiran and CYP450 enzymes in the liver

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 08 May 2020

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At a glance

Drugs Givosiran (Primary) ; Caffeine; Dextromethorphan; Losartan; Midazolam; Omeprazole
Indications Hepatic-porphyria
Focus Pharmacodynamics; Pharmacokinetics

Most Recent Events

08 May 2020 New trial record
21 Mar 2020 Results presented at the 121st Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics

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