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A Phase 1b/2 Multicenter, Open-label, Dose-escalation and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of Trastuzumab Deruxtecan (T-DXd) Monotherapy and Combinations in Adult Participants With HER2-expressing Gastric Cancer (DESTINY-Gastric-03)

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Trial Profile

A Phase 1b/2 Multicenter, Open-label, Dose-escalation and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of Trastuzumab Deruxtecan (T-DXd) Monotherapy and Combinations in Adult Participants With HER2-expressing Gastric Cancer (DESTINY-Gastric-03)

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 12 Mar 2026

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At a glance

  • Drugs Cisplatin (Primary) ; Durvalumab (Primary) ; Fluorouracil (Primary) ; Oxaliplatin (Primary) ; Pembrolizumab (Primary) ; Rilvegostomig (Primary) ; Trastuzumab-deruxtecan (Primary) ; Volrustomig (Primary) ; Capecitabine; Trastuzumab
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms DESTINY-Gastric03; DG-03
  • Sponsors AstraZeneca; AstraZeneca AB

Most Recent Events

  • 02 Mar 2026 According to Compugen Ltd media release, further clinical data anticipated from this trail is expected in this year.
  • 23 Feb 2026 Planned number of patients changed from 568 to 450.
  • 20 Oct 2025 Planned End Date changed from 30 Jul 2026 to 1 Jun 2027.

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